Tuesday, September 2, 2008

Resolution (Day -3)

Good news, we got a resolution on the question about the Rabbit-ATG.

Dr. Andersson came in just a few minutes ago and let us know that the ATG should not have been included in the treatment plan from the beginning. Why it was on the paper work that we signed is a question that has not been settled yet. However, it looks like Dr. Kebriaei caught the error sometime between us signing the papers and entering the hospital.

It’s a good thing too because if the ATG had been hung it would have basically wrecked the concept behind this transplant. This transplant is all about creating more GVH and GVL than would normally develop. ATG has two modes of action, the first is myleo-ablative (killing off marrow cells) and the second is to wipe out mature T-cells which control immune responses.

So ATG given in a normal transplant setting reduces the ability for the original immune system to "fight" back against the donor cells after they are infused. But ATG has a half-life that’s longer than a couple of days so after it is infused it acts on not only the original immune system, but the incoming bone marrow too. Which is bad if you want the marrow to come in fighting like they do in Ann's case.

Dr. Andersson was very reassuring and did an exceptional job of explaining what is going on. In addition Dr. Kebriaei is going to stop by later today and make sure every things copacetic. We're feeling better about everything already.

7 comments:

Tina said...

that is a relief to hear. glad you were able to get the explanation you needed.

Ronni Gordon said...

That's good because ATG is no fun. My nurse said they call it shake and bake because that's what it makes the patients do. Glad she didn't have to go through that experience. By the end of the first day I had so much Demoral (sp?) that I passed out.

Anonymous said...

Knowledge and understanding makes things better! I hear the confidence in your voices and that everyone is on the same page to move forward must be reassuring.
GREAT JOB!
Lea

Anonymous said...

Knowledge and understanding makes things better! I hear the confidence in your voices and that everyone is on the same page to move forward must be reassuring.
GREAT JOB!
Lea

Anonymous said...

Hello Ann and Chris!

My name is Glenna from the Asian American Donor Program. Ive been a huge lurker of your site, since I started with AADP last August. I just want to say that you both are probably the most strong, brave, and loving couple ive ever met (even if i havent formally met you, yet).

AADP has been working on a social netoworking site for all current and past blood cancer patients. We are hoping that this is will be a place where current or past patients can connect with each other, swap medication/treatment stories, update eachother, etc.

the site is called http://waitingroom.ning.com/

Please join and feel free to encourage anyone else who may benefit to join as well.

Everyone from AADP is rooting for you!!!

Sincerley,

Glenna Lee
1-800-59-DONOR

YWCA Pasadena-Foothill Valley said...

This is wonderful news, Chris and Ann. I knew you'd get it resolved!

Jennifer said...

Terrific news Chris and Ann

I, too, did not have ATG. Unlike you I am not up on all the meds, I think MTX replaced ATG in my protocol.

I am glad things are moving along -any word about preventing a delay of transplant because of the Hurricane? I am sure you are all over it.

Everyone is rooting for you and Ann
Keep fighting this beast!